Fig. 2: Connectivity in posterior cingulate cortex, thalamus, and right angular gyrus is changed after spaceflight and sustains in the longer term.
From: Prolonged microgravity induces reversible and persistent changes on human cerebral connectivity
The posterior cingulate cortex and the thalamus showed decreased participation in whole-brain connectivity (magenta), while the right angular gyrus exhibited increased participation in whole-brain connectivity (green) at postflight compared to preflight. These effects were found to persist up to 8 months after the space mission (Fol for follow-up). Significant clusters are scaled by t-statistic and slice coordinates are represented in MNI space. The plots illustrate cosmonaut-specific (gray) intrinsic connectivity contrast (ICC) changes in each significant cluster (red: mean). Subplots summarize the estimated differences between pairs of timepoints. Error bars indicate 95% confidence intervals. Statistical significance is based on p < 0.005 uncorrected at the voxel level followed by p < 0.05 corrected for family-wise error at the cluster level (n = 11). R right, L left.
