Fig. 2: Proteomics analysis of the hippocampal DG of THRSP KO mice. | Communications Biology

Fig. 2: Proteomics analysis of the hippocampal DG of THRSP KO mice.

From: Hippocampal dentate gyri proteomics reveals Wnt signaling involvement in the behavioral impairment in the THRSP-overexpressing ADHD mouse model

Fig. 2: Proteomics analysis of the hippocampal DG of THRSP KO mice.

a, b The Gene Ontology biological processes of upregulated and downregulated proteins in the hippocampal DG of adult THRSP KO mice (n = 6/group). In total, 681 and 1099 proteins are upregulated and downregulated by 0.8-fold, respectively. c Reactome pathway enrichment analysis using upregulated and downregulated proteins identified from the proteomics screen. d STRING protein–protein interaction network analysis indicates that Ctnna2 (highlighted in red), the only gene directly related to Wnt signaling, is highly interacting. Although, other Wnt signaling-related proteins were identified to exhibit an interaction. THRSP thyroid hormone-responsive protein, OE overexpressing, DG dentate gyrus, STRING Search Tool for the Retrieval of Interacting Genes/Proteins, Ctnna2 Catenin alpha-2.

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