Fig. 3: Proteomics analysis of the hippocampal DG of THRSP OE mice. | Communications Biology

Fig. 3: Proteomics analysis of the hippocampal DG of THRSP OE mice.

From: Hippocampal dentate gyri proteomics reveals Wnt signaling involvement in the behavioral impairment in the THRSP-overexpressing ADHD mouse model

Fig. 3

a, b The Gene Ontology biological processes of upregulated and downregulated proteins in the hippocampal DG of adult THRSP OE mice (n = 6/group). In total, 600 proteins are upregulated by at least 0.8-fold, whereas 832 proteins are downregulated by 0.5-fold. c Reactome pathway enrichment analysis using upregulated and downregulated proteins identified from the proteomics screen. d STRING protein–protein interaction network analysis indicates enriched interactions indicate Ctnnb1 (highlighted in blue) as the most highly interacting protein, although other Wnt signaling-related proteins were identified. THRSP thyroid hormone-responsive protein, OE overexpressing, DG dentate gyrus, STRING Search Tool for the Retrieval of Interacting Genes/Proteins, Ctnnb1 Catenin beta-1.

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