Fig. 5: Differential expressions of Wnt signaling multiprotein complex in the mouse hippocampal DG. | Communications Biology

Fig. 5: Differential expressions of Wnt signaling multiprotein complex in the mouse hippocampal DG.

From: Hippocampal dentate gyri proteomics reveals Wnt signaling involvement in the behavioral impairment in the THRSP-overexpressing ADHD mouse model

Fig. 5

a qRT-PCR analyses of multiprotein complexes. b Representative western blots, and corresponding protein levels of c p-GSK3B, d GSK3B, and e CSNK1E, the primary mediators of β-catenin phosphorylation. (n = 6 mice/group; a two-way ANOVA, Strain: F (2, 150) = 22.7, P < 0.001; Gene targets: F (9, 150) = 13.7, P < 0.001; Strain × Gene targets: F (18, 150) = 6.47, P < 0.001). c One-way ANOVA, F (2, 15) = 32.3, P < 0.001; d one-way ANOVA, F (2, 15) = 0.294, P = 0.750; e one-way ANOVA, F (2, 15) = 22.5, P < 0.001). Values are presented as the mean ±  standard error of the mean (SEM). Data indicate low expression of phosphorylated GSK3B (Ser9) in THRSP OE mice, confirming basal hyperactivity of GSK3B that could subsequently affect β-catenin. OE overexpressing, THRSP thyroid hormone-responsive protein.

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