Fig. 7: Effects of combined environmental enrichment and treadmill exercises on the ADHD-PI-like behavior in THRSP OE mice. | Communications Biology

Fig. 7: Effects of combined environmental enrichment and treadmill exercises on the ADHD-PI-like behavior in THRSP OE mice.

From: Hippocampal dentate gyri proteomics reveals Wnt signaling involvement in the behavioral impairment in the THRSP-overexpressing ADHD mouse model

Fig. 7

a Experimental schedule showing age in weeks and the commencement of rearing environment + treadmill exercises in mice. b Behavioral scheme showing the representative image, with cages where mice were exposed (standard vs. enriched environment), treadmill, and representative Y-maze heatmap image. c, d The behavior of mice exposed to SE and EE throughout the 4-week exposure to rearing environment + treadmill exercises. (n = 12 mice/group; c one-way ANOVA, F (5, 18) = 7.62, P < 0.001); d two-way ANOVA (THRSP KO), Weeks: F (1, 22) =  6.32, P = 0.020; SE/EE exposure per strain: F (1.72, 37.8) = 3.99, P = 0.032; Weeks × SE/EE exposure per strain: F (3, 66) = 2.37, P = 0.078); e two-way ANOVA (THRSP WT), Weeks: F (1, 44) = 15.8, P < 0.001; SE/EE exposure per strain: F (3, 44) = 9.69, P < 0.001; Weeks ×  SE/EE exposure per strain: F (3, 44) = 4.16, P = 0.011); f two-way ANOVA (THRSP OE), Weeks: F (1, 44) = 46.5, P < 0.001; SE/EE exposure per strain: F (3, 44) = 19.5, P < 0.001; Weeks × SE/EE exposure per strain: F (3, 44) = 2.14, P = 0.109). Values are presented as the mean ±  standard error of the mean (SEM). Environmental enrichment and treadmill exercise ameliorate behavioral deficits in THRSP OE mice. ADHD-PI attention-deficit/hyperactivity disorder predominantly inattentive, EE enriched environment, KO knockout, OE (overexpressing, SE standard environment, THRSP thyroid hormone-responsive protein. The images used in (b) was created with BioRender.com.

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