Fig. 3: Functional categorizations of ELE-induced differential gene expression, and distribution of H4K8ac and H3K27me3, are similar regardless of hippocampal hemisphere.
a, b Venn diagram of genes upregulated (a) or downregulated (b) by ELE identified between the left and right hemispheres by the separate isolation protocol TRAP-seq (n = 3 mice per group). c, d Venn diagram of Panther Gene Ontology: Biological Process terms for genes upregulated (c) or downregulated (d) by ELE identified between the left and right hemispheres by the separate isolation protocol for performing TRAP-seq. e-f Percent of genes fitting into each GO category for the left and right hemisphere for genes upregulated (e) and downregulated (f) by ELE by separate isolation TRAP-seq. g Spearman’s correlation between the left and right hemispheres TRAP-seq data from the separate isolation protocol of sedentary rlog normalized expression (R = 1, p < 2.2 × 10−16). h Spearman’s correlation between hemispheres for CUT&RUN-seq for H4K8ac normalized count data for chromosome 2 in 100 bp bins (R = 0.59, p < 2.2 × 10−16). i Spearman’s correlation between hemispheres for CUT&RUN-seq for H3K27me3 normalized count data for chromosome 2 in 100 bp bins (R = 0.7, p < 2.2 × 10−16).
