Fig. 1: Overview of stress signal transduction in L. monocytogenes.

The scheme is based on data from L. monocytogenes and Bacillus subtilis. a Stress signal pathway from signal sensing to response via the stressosome. The stressosome core is drawn based on the cryoEM structure²¹. b Model of regulation of SigB activity via the stressosome. RsbT is freed from the stressosome following activation of its kinase activity upon receiving stress signals. RsbT then associates with RsbU, which triggers the dephosphorylation of RsbV and the subsequent release of SigB from RsbW. RsbX is a phosphatase that restores the sensing-ready state of the stressosome.