Fig. 6: HNRNPK-MYC signaling pathway perturbation in lung cancer. | Communications Biology

Fig. 6: HNRNPK-MYC signaling pathway perturbation in lung cancer.

From: Single-cell RNA binding protein regulatory network analyses reveal oncogenic HNRNPK-MYC signalling pathway in cancer

Fig. 6

a, b Pathways enriched by potential targets of HNRNPK. a was based on single cell RNA-seq data and b was for TCGA bulk transcriptome analysis. c Venn plot showing the overlap of pathways in single-cell and bulk transcriptomes. d, e Enrichment plots of MYC target pathway identified by genes coexpressed with HNRNPK in lung cancer. d for single cell transcriptome analysis and e for bulk transcriptome analysis. f Genome visualization of HNRNPK binding with MYC in cell lines. g Relative protein expression of MYC in overexpression or knockdown of HNRNPK lung cancer cells. Error bars represent the standard errors. h IHC of MYC in overexpression or knockdown of HNRNPK lung cancer cells.

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