Fig. 1: Visualization of liver zonation using spatial transcriptomics.
From: Murine breast cancers disorganize the liver transcriptome in a zonated manner
a Alb and Cyp2e1 expressions in one of the sham samples. A second sample is shown in Supplementary Fig. 1. b Volcano plot of the module scores of 2898 GO terms. The x-axis shows the difference in module scores between Albhigh and Cyp2e1high zones. The y-axis shows the p-values (−log10) of a Wilcoxon Rank Sum test. Supplementary Fig. 2 shows the same plot with more GO terms indicated. c–h UMAP plots of the Visium spots of the two sham samples. c UMAP_1 is anti-correlated with Alb expression. Spots on the left side represent the periportal zone with high Alb expression. Genes involved in the ATP synthesis coupled electron transport (d) and the aspartate family amino acid metabolism (e) have high activity in the periportal zone. f UMAP_1 is correlated with Cyp2e1 expression. Spots on the right side represent the pericentral zone with high Cyp2e1 expression. Genes involved in the xenobiotic catabolic process (g) and the bile acid and bile salt transport (h) have high activity in the pericentral zone.
