Fig. 1: snRNA-seq analysis from human muscle identifies 3 FAP populations. | Communications Biology

Fig. 1: snRNA-seq analysis from human muscle identifies 3 FAP populations.

From: MME+ fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle

Fig. 1

a Violin plots of logcounts values from well-known marker genes of FAPs (PDGFRA, DCN and CD34) and adipocytes (PLIN1, PPARG and ADIPOQ), color-coded by the identified subpopulations. b TSNE plot of FAP and adipocyte populations from human muscle, color-coded by the identified subpopulations. c TSNE plots of expression levels of marker genes from the different subpopulations, color-coded by logcounts values. d Dot plots showing upregulated or downregulated pathways from GSEA of FAPs 1 vs FAPs 2 (left panel), FAPs 1 vs FAPs 3 (middle panel) or FAPs 2 vs FAPs 3 (right panel). X-axis indicates the normalized enrichment score (NES) for each pathway. Color and size of the dots indicate adjusted p-values (FDR). Significant values are delimited by the red dashed line (Adjusted p < 0.05 or -log10(adjusted p-value) >1.3). e, f Bar plots showing average Z-score of GSVA of adipogenesis pathways from Hallmark (MsigDB) (e) and WikiPathways databases (f). Color-coded by identified FAPs subpopulations. ***p < = 0.001, ****p < = 0.0001.

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