Fig. 3: OB precludes ThrRS binding of l-threonine and tRNA.
From: Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion
a Superimposition of the ThrRS-l-Thr structure (blue cartoons, PDB code: 1EVK) with the ThrRS-OB structure (light cyan cartoons). OB is shown as orange sticks. l-Thr is shown as black sticks. H-bonds are shown as green dashed lines. Coordination bonds are shown as cyan lines. b Superimposition of the ThrRS-tRNAThr structure (yellow cartoons, PDB code: 1QF6) with the ThrRS-OB structure (light cyan cartoons). The nitrophenyl group forms stacking interactions with Tyr313 and Arg363, which also interact with tRNA A76 in a similar way.
