Fig. 2: Recurrent CHD associated CNV-lncRNAs in heart-correlated coexpression modules.
a Distribution of recurrent non-syndromic (n = 19) and syndromic CHD (n = 21) associated CNVs on human chromosomes are shown. The colors of the bands represent CHD case types in which CNVs were reported. The colors of the fonts represent CNV types. b Positively heart-correlated (r > 0.6, n = 2) coexpression modules (the black and darkgreen modules) constructed with human organ developmental dataset (n = 313) were identified (Supplementary Data 1). The y axis represents different CNV-lncRNA coexpression modules. Values of Pearson correlation coefficient (r) to heart tissue are shown on the x axis. The red dashed lines indicate |r| = 0.6. Sizes of the nodes represent CNV-lncRNAs count in each module. Colors of the nodes represent values of −log10(Padj). Adjusted P value was caluculated with corPvalueStudent function in WGCNA R package. c Functional annotations of the positively heart-correlated coexpression modules are shown (Supplementary Data 2). Horizontal bars represent GO terms, and the colors of the bars represent different CNV-lncRNA coexpression modules. For each positively heart-correlated module, the top five GO terms (ranked by Padj) are listed on the y axis. Values of −log10(Padj) are shown on the x axis. The red dashed line indicates Padj of 0.05. d Classifications of CNV-lncRNAs in the black module. Counts for each class of the CNV-lncRNAs are shown in the parentheses. e Sequence conservation of the CNV-lncRNAs in the black module (Supplementary Data 3).
