Fig. 4: Muller plots showing the dynamics of sbmA and fusA allele frequencies during the evolution of biofilm and planktonic populations subjected to intermittent amikacin treatment.
From: Intermittent antibiotic treatment of bacterial biofilms favors the rapid evolution of resistance
An independent muller plot showing the dynamic of sbmA and fusA alleles frequencies over cycles of evolution is shown for each population. Every mutation is displayed with a unique colour through all plots. Due to the limit of detection, only mutations with frequency above 5% frequency are shown. Information regarding sbmA and fusA have been extracted from whole-population sequencing presented in supplementary Data 3.
