Fig. 5: Association of non-synonymous mutations in sequenced evolved clones and their corresponding MICs to amikacin.
From: Intermittent antibiotic treatment of bacterial biofilms favors the rapid evolution of resistance
Non-synonymous mutations identified by whole genome sequencing in clones of E. coli coming from AMK intermittently treated biofilm (a) and planktonic (b) populations. MICs are expressed in µg/mL. MIC of the ancestor strain is 16 µg/mL and is shown in the first top left cell. In a and b the first column actually corresponds to clones that had a unique mutation in the indicated genes. The presented information is extracted from clone sequencing data presented in supplementary Data 4.
