Fig. 1: γ-irradiation induces CD47 overexpression.
From: The DNA damage response pathway regulates the expression of the immune checkpoint CD47
a Representative histogram of CD47 staining and flow cytometric analysis before and after γ-irradiation (HEK-293T cells). b Dose-dependent expression of CD47 (MFI) in HEK-293T cells 24 h after γ-irradiation. c Time-dependent expression of CD47 (MFI) in HEK-293T cells following 20Gy γ-irradiation. d CD47 expression (MFI) in CHO cells transfected with human CD47 24 h after γ-irradiation. e Representative histogram of CD47 staining of CHO_CD47 of different clones (left panel) and their corresponding CD47 expression (MFI) in response to 20 Gy γ-irradiation (right panel). Graphs show an average (±STD) of four replicates in each group. One of at least four independent experiments is shown. *p < 0.05; **p < 0.005; ***p < 0.0005.
