Fig. 5: Analysis of the number of contacts between C-terminal LC residues and hinge region.
From: Effect of Fc core fucosylation and light chain isotype on IgG1 flexibility
Box plots showing the distribution of the number of contacts between C-terminal LC residues and hinge in adalimumab (a) and avelumab (b). The number of frames considered in these analyses is: n = 2649 for adalimumab G0, n = 3440 for adalimumab G0F, n = 3170 for avelumab G0, n = 4110 for avelumab G0F. Structural representation of G0 adalimumab (c) and avelumab (d) to highlight the structural proximity between C-terminal LC residues and the hinge. The secondary structure of Fab domains is shown as lines, the LC residues are shown as sticks, and the molecular surface of the hinge is shown in gray. For clarity, Fc is not displayed.
