Fig. 1: Hepatic Acly expression is increased in aging mice. | Communications Biology

Fig. 1: Hepatic Acly expression is increased in aging mice.

From: Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging

Fig. 1

a Body weight. n = 4. One-way ANOVA. b Tissue weight. n = 4. One-way ANOVA. c OGTT. n = 8. Two-way ANOVA repeated measures. d Area under the curve (AUC) of the OGTT. n = 8. One-way ANOVA. e Insulin levels during an OGTT. n = 8. Two-way ANOVA repeated measures. f AUC of insulin levels during an OGTT. n = 8. One-way ANOVA. g IPPTT. n = 8 for young, n = 8 for adult, n = 7 for old. Two-way ANOVA repeated measures. h AUC of the IPPTT. n = 8 for young, n = 8 for adult, n = 7 for old. One-way ANOVA. i Insulin tolerance test (ITT). n = 7 for young, n = 7 for adult, n = 6 for old. Two-way ANOVA repeated measures. j AUC of the ITT. n = 7 for young, n = 7 for adult, n = 6 for old. One-way ANOVA. k Circulating glucose levels at 16 h of fasting. n = 8. One-way ANOVA. l Circulating insulin levels at 16 h of fasting. n = 8 for young, n = 6 for adult, n = 8 for old. One-way ANOVA. m HOMA-IR index. n = 8 for young, n = 6 for adult, n = 8 for old. One-way ANOVA. n Acly gene expression. n = 3–4. a.u.: arbitrary units. r.u.: relative units. BAT: Brown adipose tissue. Gastroc: Gastrocnemius. Ud: Under the threshold of detection. Data shown are the means ± SEM. *p < 0.05 Old vs. Young; #p < 0.05 Adult vs. Old; &p < 0.05 Young vs. Adult.

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