Fig. 3: SB-204990 improves physical health in mice fed with HFD. | Communications Biology

Fig. 3: SB-204990 improves physical health in mice fed with HFD.

From: Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging

Fig. 3

a Circulating glucose levels in fasting conditions at week 14 of treatment. n = 10 for STD. n = 9 for STD-SB. n = 9 for HFD. n = 9 for HFD-SB. Two-way ANOVA. b Circulating insulin levels in fasting conditions at week 14 of treatment. n = 10 for STD. n = 9 for STD-SB. n = 9 for HFD. n = 9 for HFD-SB. Two-way ANOVA. c HOMA-IR index at week 14 of treatment. n = 10 for STD. n = 9 for STD-SB. n = 9 for HFD. n = 9 for HFD-SB. Two-way ANOVA. d Percentage of glycated hemoglobin (HbA1c) in blood at week 15 of treatment. n = 8 for STD. n = 8 for STD-SB. n = 10 for HFD. n = 8 for HFD-SB. Two-way ANOVA. e LDL/VLDL levels in serum at week 15 of treatment. n = 7 for STD. n = 8 for STD-SB. n = 8 for HFD. n = 8 for HFD-SB. Two-way ANOVA. f Total cholesterol levels in serum at week 15 of treatment. n = 6 for STD. n = 6 for STD-SB. n = 6 for HFD. n = 8 for HFD-SB. Two-way ANOVA. g Time to fall in an accelerating rotarod at week 8 of treatment. n = 11 for STD. n = 11 for STD-SB. n = 10 for HFD. n = 11 for HFD-SB. Two-way ANOVA. h Time to fall in wire hang test at week 10 of treatment. n = 11 for STD. n = 11 for STD-SB. n = 9 for HFD. n = 10 for HFD-SB. Two-way ANOVA. i Tissue weights. n = 10 for STD. n = 9 for STD-SB. n = 10 for HFD. n = 9 for HFD-SB. Two-way ANOVA. j Representative images of hematoxylin and eosin staining on several tissues. Scale 200 µm. n = 6 for STD. n = 7 for STD-SB. n = 5 for HFD. n = 6 for HFD-SB. k Adipocyte mean area. n = 6 for STD. n = 7 for STD-SB. n = 5 for HFD. n = 6 for HFD-SB. Two-way ANOVA. l Serum ALT levels in fasting conditions at week 14 of treatment. n = 10 for STD. n = 9 for STD-SB. n = 10 for HFD. n = 9 for HFD-SB. Two-way ANOVA. m Serum AST levels in fasting conditions at week 14 of treatment. n = 10 for STD. n = 9 for STD-SB. n = 10 for HFD. n = 9 for HFD-SB. Two-way ANOVA. SB: SB-204990. STD: standard diet. HFD: high-fat diet. BAT: Brown adipose tissue. Gastroc: gastrocnemius. SKM: skeletal muscle. a.u.: arbitrary units. Data shown are the means ± SEM. Unless otherwise highlighted, *p < 0.05 STD-SB vs. STD. #p < 0.05 HFD-SB vs. HFD.

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