Fig. 2: NetBID identified distinct hub genes and associated signaling pathways of RRM2 and RRM2B in HB and HCC patient tumors.

a The RRM2 and RRM2B networks in 88 HB patient tumors inferred by SJARACNe. Edge width corresponds to the correlation strength measured by mutual information. Red and blue edges indicate positive and negative correlations between the expression of RRM2 or RRM2B and their individual hub genes. b Venn plot showing the overlap of the four indicated RRM2 and RRM2B hub gene lists identified in HB patient tumors. c The RRM2 and RRM2B networks in 374 HCC patient tumors similarly defined as in (a). d Venn plot showing the overlap of the four indicated RRM2 and RRM2B hub gene lists identified in HCC patient tumors. e Gene set enrichment analysis of HALLMARK and KEGG gene sets of the 4 hub gene lists using Fisher’s Exact Test. The size and color intensity indicate the odds ratio and statistical significance, respectively. The P values of the bar plot were combined from HB and HCC primary patient cohorts using the Stouffer method.