Fig. 5: Both RRM2 and RRM2B contribute moderately to HepG2 cell drug resistance. | Communications Biology

Fig. 5: Both RRM2 and RRM2B contribute moderately to HepG2 cell drug resistance.

From: Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse

Fig. 5: Both RRM2 and RRM2B contribute moderately to HepG2 cell drug resistance.The alternative text for this image may have been generated using AI.

a The dose-response curves of tdT, RRM2OE and RRM2BOE HepG2 cells to the indicated drugs (n = 3 for each group). b List of the drug IC50 values and their comparisons between tdT, RRM2OE and RRM2BOE HepG2 cells. c The dose-response curves of control (wildtype), RRM2BKO1 and RRM2B KO1/Res HepG2 cells to the indicated drugs (n = 3 for each group). d List of the drug IC50 values and their comparisons between control (wildtype), RRM2BKO1 and RRM2B KO1/Res HepG2 cells. Extra Sum of Square F test was performed for (b, d). Statistically significant P values (<0.05) were indicated by bold font.

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