Fig. 6: RRM2B, not RRM2, supports post-drug treatment recovery of HB cells in vitro.
From: Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse
a 12-day colony formation assay of the indicated RRM2- and RRM2B-manipulated HepG2 cells post cisplatin treatment at two different concentrations. b, c Quantitative comparison the colony area occupied by cells in (A) (n = 3 for each group). Student t test. P values: * <0.05, ** <0.01, *** <0.001. d Gene set enrichment analysis of HALLMARK and KEGG gene sets using pre-ranked gene list by fold change of gene expression across different comparisons of the indicated HB cells and patient tumors. The size and color intensity of the bubbles indicate the normalized enrichment score and statistical significance, respectively. e Immunoblotting of the indicated proteins in the cisplatin-treated RRM2BKO cells.
