Fig. 8: RRM2B level is associated with drug response in HB patient tumors.
From: Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse
a H&E staining, RNAscope staining for RRM2 and RRM2B on serial sections of three post-chemotherapy primary HB patient tumors. Open arrows in (iii, iv): RRM2+/RRM2B− cells in viable tumor areas; arrows in (vii, viii) and (xi, xii): cells with evident RRM2B expression but not RRM2 expression in the tumor areas stressed by chemotherapy. Images on the same column share the same scale bar. b RRM2 and RRM2B immunoblotting of two primary HB patient tumors collected post-chemotherapy. c A working model of RRM2 and RRM2B subunit switching in HB growth, drug response, and relapse.
