Fig. 1: MIR125B2 is imprinted in the human brain and adrenal gland.
From: Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice
a Schematic of human induced pluripotent stem cells (hiPSCs), hiPSCs-derived cortical neurons, tissues, disease status of tissues, and corresponding gender and age of hiPSCs and tissues in this study. b Schematic of MIR125B2 genomic locus and all SNP sites used in this study. Arrow indicates the direction of transcription; the number indicates nucleotide positions relative to the transcription start site of MIR125B2. Lengths of sequences between SNP sites are not drawn to scale. c Parent-of-origin-specific allelic expression of MIR125B2 in normal and tumor tissue from the temporal cortex of a 17-year-old female was determined by Sanger sequencing. d Parent-of-origin-specific allelic expression of MIR125B2 in the prefrontal cortex of a 29-year-old female was determined by Sanger sequencing. e Parent-of-origin-specific allelic expression of MIR125B2 in the prefrontal cortex of a 32-year-old female was determined by Sanger sequencing. Parent-of-origin-specific allelic expression of MIR125B2 in the human induced pluripotent stem cells (hiPSCs) and hiPSCs-derived cortical neurons from 16-year-old twin brothers (f) and (g). h Parent-of-origin-specific allelic expression of MIR125B2 in the adrenal gland from a 45-year-old female (normal and tumor tissue) was determined by Sanger sequencing. “P” = paternal expression. “I” = imprinting expression. Single nucleotide polymorphism site is indicated by the gray column.
