Fig. 7: Effect and mechanism of LncAABR07053481 on the repair of early SANFH by regulating the Notch1 pathway to inhibit hypoxia-induced apoptosis of BMSCs: LncAABR07053481 acts as a sponge for miR-664-2-5p to attenuate its repressive effect on Notch1 and activates the Notch1 pathway and releases NICD1 (the intracellular active fragment of Notch1) from the cell membrane. | Communications Biology

Fig. 7: Effect and mechanism of LncAABR07053481 on the repair of early SANFH by regulating the Notch1 pathway to inhibit hypoxia-induced apoptosis of BMSCs: LncAABR07053481 acts as a sponge for miR-664-2-5p to attenuate its repressive effect on Notch1 and activates the Notch1 pathway and releases NICD1 (the intracellular active fragment of Notch1) from the cell membrane.

From: LncAABR07053481 inhibits bone marrow mesenchymal stem cell apoptosis and promotes repair following steroid-induced avascular necrosis

Fig. 7

NICD1 localizes to the nucleus, where it forms a transcriptionally active complex with the DNA-binding protein CSL and the coactivator Mastermind (MAM) to upregulate transcription of Notch target genes (Survivin and Bcl-2). Following which, hypoxia-induced apoptosis of BMSCs in the area of osteonecrosis is inhibited, improving the transplantation effect of BMSCs on early SANFH.

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