Fig. 1: SB2301 reduces cellular LDs without inducing cytotoxicity. | Communications Biology

Fig. 1: SB2301 reduces cellular LDs without inducing cytotoxicity.

From: SB2301-mediated perturbation of membrane composition in lipid droplets induces lipophagy and lipid droplets ubiquitination

Fig. 1

A Chemical structure of SB2301 (4). B Representative LD fluorescence images captured during phenotypic screening. C The quantification of cellular LD count in HeLa cells upon treatment with various SB2301 doses for 24 h. All data are shown as the mean ± standard deviation (SD). D Dose-response curves of cell viability upon SB2301 treatment for the indicated times in HeLa cells. All data are shown as the mean ± SD. E TG quantification results upon SB2301 treatment for 24 h in HepG2 cells. All data are represented as dot plots with the mean ± SD, (n = 3). Data were analyzed using an unpaired t-test. **P = 0.0068 vs. dimethyl sulfoxide (DMSO), ##P = 0.0029 vs. DMSO.

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