Fig. 6: LD-reducing effects on in vitro drug-induced steatosis models. HepG2 cells were treated with 75 μM of oleic acid (OA) or 10 μM of tamoxifen (TM) for 24 h to induce steatosis followed by SB2301 treatment for an additional 24 h. | Communications Biology

Fig. 6: LD-reducing effects on in vitro drug-induced steatosis models. HepG2 cells were treated with 75 μM of oleic acid (OA) or 10 μM of tamoxifen (TM) for 24 h to induce steatosis followed by SB2301 treatment for an additional 24 h.

From: SB2301-mediated perturbation of membrane composition in lipid droplets induces lipophagy and lipid droplets ubiquitination

Fig. 6

A Representative live-cell fluorescence LD images of SB2301 in OA- and TM-treated hepatic steatosis models. B Quantification results of cellular LD count and area from A. All data are represented as dot plots with the mean ± SD, (n = 3). Data were analyzed using an unpaired t-test. ****P < 0.0001, ***P = 0.001, $$$P = 0.0002 vs. DMSO, ###P = 0.0004, **P = 0.0093 vs. DMSO.

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