Fig. 2: Comparing and integrating the data of other screens.
a Heatmap of Pearson correlation coefficients among all pairs of screens. b Venn diagram depicting the comparison of different screening studies with normalized data. The 457 overlapping genes were defined as the common set, whereas all the other genes were defined as the context-specific set (Supplementary Data 5). c Expression levels of the “core TFs”, “common”, “context-specific” and “non-essential genes” in mESCs. The data are represented as log10 (RPKM + 1). d Cluster dendrogram and module assignment for modules from WGCNA. Common and context-specific genes were clustered based on a topological overlap matrix (TOM). The branches correspond to modules of highly interconnected groups of genes. Colours in the horizontal bar represent the modules. Six modules with 3303 genes were detected. e Heatmap of the relationships between the modules and samples. Colours in the longitudinal bar represent the modules. The red cells correspond to positive correlation. The yellow cells correspond to negative correlation. The numbers in the cell indicate the correlation coefficient (upper) and p-value (below). Colour intensity is proportional to the correlation coefficient.
