Fig. 8: Association of module activity with tumour subtype and prognostic outcome in gliomas.
a The boxplots show the gene expression of each module in normal, LGG and GBM samples. Boxes show interquartile range, whiskers show fixed multiples of interquartile range and center line shows average gene expression values (log2). LGG, low-grade gliomas. GBM, glioblastoma multiform. b Enrichment patterns of modules in normal, LGG and GBM group samples. Numbers indicate the enrichment significance (-log2 (p-value)) of module genes within each sample group. Red (positive value) indicates enrichment for high-expression, and blue (negative value) indicates enrichment for low-expression. Colour intensity corresponds to the -log2 (p-value). c Kaplan–Meier analyses of the progression-free interval in patients. Patients with high module activities (50% cut-off) are labelled red, whereas patients showing low module activities (50% cut-off) are labelled blue. p values are calculated using the log-rank test.
