Fig. 7: A schematic model of the UBAP2L-snoRNA complex in SG. | Communications Biology

Fig. 7: A schematic model of the UBAP2L-snoRNA complex in SG.

From: The association of UBAP2L and G3BP1 mediated by small nucleolar RNA is essential for stress granule formation

Fig. 7

a In the nucleus, snoRNAs are produced by introns and complex with NOP56 and NOP58 as snoRNPs and matured by endonucleases. Some snoRNAs are produced in the cytoplasm. UBAP2L and G3BP1 complex with C/D box snoRNAs in the cytoplasm. Once cells are stimulated by stress, SGs are formed normally. The cells can adjust to the stress conditions to survive. b When the expression of C/D box snoRNAs is reduced by NOP56 or NOP58 depletion, UBAP2L and G3BP1 cannot form a complex. The number of SGs is reduced, and it is difficult for the cell to adjust to stress.

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