Fig. 4: Structural details of interactions between the BA.1 RBD and 1H1 Fab for potent and broad neutralization.
From: Mechanism of a rabbit monoclonal antibody broadly neutralizing SARS-CoV-2 variants
a overall structural model of BA.1 RBD in complex with 1H1 Fab and its CDRs are labeled. b the footprints of 1H1 are represented as surface and colored with dark cyan. The BA.1 RBD residues recognized by 1H1 are listed and a key interaction residue R346 of the BA.1 RBD is colored red. c–f the detailed interactions between the BA.1 RBD and 1H1 Fab including 1H1 heavy chain (c), 1H1 light chain (d, e) and the key residue R346-related interactions (f). The interacting residues of BA.1 RBD are shown as yellow sticks, the 1H1 heavy chain residues are shown as dark cyan sticks and the light chain residues are shown as light green sticks. Potential hydrogen bonds are represented as cyan dashed lines and salt bridges are represented by magenta lines, respectively.
