Fig. 4: PBCT induces cell death upregulation and cell viability downregulation pathways in association with cytoskeleton remodeling and cellular communication. | Communications Biology

Fig. 4: PBCT induces cell death upregulation and cell viability downregulation pathways in association with cytoskeleton remodeling and cellular communication.

From: Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model

Fig. 4

a, b Functional enrichments analysis of differentially expressed genes with Venn diagrams of gene expression profiles in proton vs mock proton and in proton boron vs mock proton. c Specific biological pathways analysis by DAVID software of upregulated transcripts in which dots are key colored according to their – log(p-value) and their dimensions are proportioned to counts number. d, e Specific statistically significant pathways analysis by IPA software and detailed IPA analysis of death/survival balance. f Data enrichment analysis with most statistically and biologically relevant pathway in GBM tumor sample derived from mock proton versus proton boron treated mice in which dots are key colored according to their z-score and their dimensions are proportioned to their – log(p-value).

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