Table 1 Combinations of parameters used in the optimization of phenetic clustering of SARS-CoV-2 genomes.

From: HaploCoV: unsupervised classification and rapid detection of novel emerging variants of SARS-CoV-2

Freq. Threshold

Pers. Threshold

VOC > 1HG/Tot VOC

VOC > 1HG/ Tot VOI

VUM > 1HG/Tot VUM

Tot HGs

0.5

10

5/5

9/9

14/14

7936

0.5

15

5/5

9/9

14/14

5854

0.5

25

5/5

9/9

14/14

4799

0.5

50

4/5

8/9

10/14

4076

0.5

75

3/5

7/9

9/14

3960

0.5

100

2/5

4/9

8/14

2957

1

10

5/5

9/9

14/14

2979

1

15

5/5

9/9

14/14

1571

1

25

5/5

9/9

13/14

976

1

50

5/5

8/9

13/14

863

1

75

4/5

7/9

11/14

801

1

100

2/5

5/9

8/14

736

2.5

10

5/5

8/9

11/14

1360

2.5

15

5/5

7/9

10/14

1182

2.5

25

5/5

7/9

10/14

938

2.5

50

2/5

6/9

10/14

801

2.5

75

2/5

5/9

4/14

736

2.5

100

2/5

4/9

4/14

583

5

10

5/5

7/9

6/14

768

5

15

2/5

4/9

6/14

659

5

25

2/5

3/9

4/14

482

5

50

1/5

2/9

4/14

424

5

75

1/5

1/9

2/14

401

5

100

1/5

1/9

2/14

388

  1. Freq. Threshold: minimum frequency threshold. Pers. Threshold: minimum number of days above the minimum AF threshold. VOC > 1HG/Tot VOC: number of VOC for which at least 1 HG was designated compared to the total number of VOC. VOC > 1HG/Tot VOI: number of VOI for which at least 1 HG was designated compared to the total number of VOI. VUM > 1HG/Tot VUM: number of VUM for which at least 1 HG was designated compared to the total number of VUM. Tot HGs Total number of HGs identified.