Fig. 2: Tet(X6) confers pan tetracycline resistance. | Communications Biology

Fig. 2: Tet(X6) confers pan tetracycline resistance.

From: Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases

Fig. 2

a Chemical structures of different tetracyclines. b Tet(X6) confers high minimum inhibitory concentrations (MIC). Abbreviations: tetracycline (TET); doxycycline (DOX); chlortetracycline (CTC); omadacycline (OMA); tigecycline (TIG); eravacycline (ERA); anhydrotetracycline (aTC). c Michaelis-Menten curves for Tet(X6)-catalyzed degradation of tetracycline antibiotics. Note that the 65 µM data point for eravacycline is omitted for uniform scale on the x-axis and the full plot is provided as Supplementary Fig. 5. d Apparent Km, kcat, and catalytic efficiencies (kcat/Km) of Tet(X6) against different tetracyclines. Error values represent standard deviations for three independent trials.

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