Fig. 3: Anhydrotetracycline rescues Tet(X6)-mediated inactivation of tetracycline antibiotics. | Communications Biology

Fig. 3: Anhydrotetracycline rescues Tet(X6)-mediated inactivation of tetracycline antibiotics.

From: Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases

Fig. 3

a Whole cell inhibition of E. coli expressing tetracycline destructase enzymes. Abbreviations: tetracycline (TET); anhydrotetracycline (aTC). b Calculated FICI. c In vitro aTC inhibition of Tet(X6) degradation of tetracycline antibiotics as observed via an optical absorbance assay. IC50 values of each curve are shown. Error values represent standard deviations for three independent trials.

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