Fig. 7: Pyrin domain of NLRP3 prefers oxidized over non-oxidized mtDNA.
From: Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation
a NLRP31-93 pyrin domain was eluted from biotinylated oxidized or non-oxidized mtDNA coated streptavidin Dynabeads with increasing concentrations of unlabeled oxidized or non-oxidized mtDNA. A representative gel of each membrane of each shown (n = 3). b Fraction bound vs. LOG unlabeled mtDNA for elution with oxidized or non-oxidized mtDNA. Raw data plotted. The dashed line represents a 95% confidence interval of best-fit line (solid line), n = 3.
