Fig. 7: Inhibition of Notch signaling has a differential effect on tumor growth and survival in mice bearing subcutaneous tumors seeded by metastatic cell lines.
From: Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer
a Mice were injected subcutaneously with 2 M cells from UT-SCC-74A and UT-SCC-74B transduced with inducible shRNA for Notch3. When tumors reached 200 mm3 the mice were separated into control and treatment groups; the later received doxycycline in their food. The tumors were measured weekly using caliper until mice reached experimental endpoint. b Survival analysis of control and doxycycline treated mice.
