Fig. 2: Regional association plots in mouse and human.

a At the top are shown P-values for SNPs in the mouse chromosome 5 region homologous to human 22q12.1 . Dot colors reflect LD with the index SNP (rs32069343). Underneath are shown genes annotated in the region. b Effect of rs32069343 on mouse skull shape (expansion/contraction relative to the mean shape is shown in blue/brown). To facilitate visualization, the effect has been magnified ×20 (see also Supplementary Movie). c LocusZoom plot for 22q12.1: the top panel shows SNP P-values (dot color reflecting LD with the index SNP rs9608473). The bottom panel displays genes annotated in the region. d, e Facial landmarks placed by Face++ (dark dots indicate the landmarks retained in ILD calculation). Lines indicate ILDs associated with SNPs in 22q12.1. In d line color reflects association P-value; in e line color reflects the direction and magnitude of the association. The ILD with strongest association P-value (D437) is labelled.