Table 1 Features of nine genome regions reported in previous face GWASs for which genome-wide significant association is also observed here.

From: Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape

Chromosomal region

Index SNP

Candidate gene

# significant ILDs

# significant SNPs

Strongest P-value

Refs.

2q12.3

rs72627476

EDAR

75

1245

5.60 × 10−34

1,2,8

7p14.1

rs846315

GLI3

5

31

1.20 × 10−12

1,15

2q36.1

rs13022712

PAX3

18

37

6.42 × 10−12

2,4,8,9,10,11,15,17

5q13.2

rs7341037

FOXD1

10

18

1.49 × 10−10

31

6p21.1

rs141680515

SUPT3H/RUNX2

15

275

1.68 × 10−10

1,2,4,8,11,15

15q21.1

rs1426654

SLC24A5

2

4

1.74 × 10−10

2

4q31.3

rs2045323

DCHS2/SFRP2

8

64

9.35 × 10−10

1,2,4,15

5p12

rs4505960

FGF10

3

1

2.43 × 10−8

15

15q25.2

rs62027787

ADAMTSL3

1

3

2.65 × 10−8

15

  1. Genes underlined include significantly associated SNPs. Genes in bold include an associated SNP leading to an amino-acid substitution.
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