Table 2 Features of the five novel face loci discussed in the texta.

From: Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape

Region

Index SNP

Alleles (Ref/Alt)

Association P-value

# Significant ILDs

# Significant SNPs

Replication P-valueb

Alternative allele frequencyc

Main candidate genes

 

CAN

NAM

EUR

AFR

 

1q32.3

rs12564392

C/A

2 × 10−8

3

3

1 × 10−2

0.28

0.61

0.01

0.00

ATF3

3q21.1

rs820360

A/G

5 × 10−10

8

3

1 × 10−3

0.35

0.32

0.37

0.06

MYLK

8p11.21

rs59547557

T/C

7 × 10−10

7

39

3 × 10−3

0.48

0.31

0.55

0.81

ADAM3A

10p11.1

rs58831446

A/AT

1 × 10−10

8

25

2 × 10−4

0.51

0.66

0.41

0.44

ZNF25

22q12.1

rs9608473

G/A

1 × 10−8

6

11

1 × 10−3

0.29

0.49

0.10

0.07

SEZ6L/MN1

  1. aInformation on all the regions detected is in Supplementary Table 4.
  2. bSmallest P-value observed in the Chinese or European replication samples.
  3. cAlternative allele frequency of index SNP in: CANDELA (CAN); Sub-Saharan Africans (AFR); Europeans (EUR)97 and Native Americans (NAM)76.
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