Fig. 1: Somatic mutational landscape of head and neck angiosarcoma. | Communications Biology

Fig. 1: Somatic mutational landscape of head and neck angiosarcoma.

From: Spatial transcriptomics reveal topological immune landscapes of Asian head and neck angiosarcoma

Fig. 1: Somatic mutational landscape of head and neck angiosarcoma.The alternative text for this image may have been generated using AI.

a Oncoplot of somatic non-synonymous variants of interest, including recurrent mutations in CSMD3 (18%), LRP1B (18%), MUC16 (18%), POT1 (16%), and TP53 (16%). The median tumor mutation burden (TMB) was 4.28 mutations per coding megabase (mt/Mb) (range, 0.03–13.4). b TMB was significantly higher in UV compared to non-UV-related AS-HN (median, 4.63 vs 3.30 mt/Mb, p = 0.0294 by Mann–Whitney U test). Violin plots are represented by median and lower to upper quartile values, and the vertical line extends from the minimum to the maximum value. No significant difference in TMB was observed between HHV-7-positive and HHV-7-negative tumors.

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