Fig. 4: Spatial transcriptomic profiling of head and neck angiosarcomas representing four putative pathogenic etiologies. | Communications Biology

Fig. 4: Spatial transcriptomic profiling of head and neck angiosarcomas representing four putative pathogenic etiologies.

From: Spatial transcriptomics reveal topological immune landscapes of Asian head and neck angiosarcoma

Fig. 4: Spatial transcriptomic profiling of head and neck angiosarcomas representing four putative pathogenic etiologies.The alternative text for this image may have been generated using AI.

UMAP plots of merged spatial datasets showing (a) the distribution by samples (AS-17: UV-positive, HHV-7-positive, and immune hot; AS-52: UV-positive, HHV-7-negative, and immune intermediate; AS-03: UV-negative, HHV-7-positive, and immune intermediate; AS-07: UV-negative, HHV-7-negative, and immune cold) and (b) the distribution of seven clusters annotated with their predominant cell types. c–f Spatial projections of the UMAP spot transcriptome clusters onto their respective tissue sections revealed important information about the tumor microenvironment.

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