Fig. 5: Electrostatic interactions at the interfaces formed by the OGDHc components.
From: Structural analysis of an endogenous 4-megadalton succinyl-CoA-generating metabolon
A AI-derived model of the E1o-LD interaction. Overall model, energetics (VdW Van der Waals interactions, DS Desolvation energy, ES Electrostatics) and buried surface area (BSA), and the overall charge of its interaction interface with the LD can be seen in left, middle and right respectively. B AI-derived model of the E2o-LD interaction. Overall model, energetics and buried surface area, and the overall charge of its interaction interface with the LD can be seen in left, middle and right respectively. C AI-derived model of the E3-LD interaction. Overall model, energetics and buried surface area, and the overall charge of its interaction interface with the LD can be seen in left, middle and right respectively. D AI-derived model of the ordered LD domain of E2o. Lys42 carries the lipoyl-moiety. A highly negatively charged interaction interface is observable. Original values for plotting can be found in Supplementary Data 5.
