Fig. 4: Identification of the MuRF1-dependent skeletal muscle ubiquitinome signature induced by tumor burden. | Communications Biology

Fig. 4: Identification of the MuRF1-dependent skeletal muscle ubiquitinome signature induced by tumor burden.

From: Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth

Fig. 4

a Principal component analyses of the skeletal muscle ubiquitin-modified proteome during the progression of KPC tumor burden in WT and MuRF1-/- mice. b, c Number of diGly sites (b) and proteins (c) showing altered ubiquitination levels in each genotype in response to KPC-tumor burden. d Number of proteins showing altered ubiquitination levels at 1, 2, 3, 4, and ≥ 5 diGly sites in each genotype. e–i Enriched GO and KEGG terms associated with proteins showing increased ubiquitination in response to tumor burden in WT mice. j Number of diGly sites and proteins showing increased ubiquitination in response to tumor burden in skeletal muscle of WT mice but not in MuRF1-/- mice, indicating MuRF1-dependence. k–o Enriched GO and KEGG terms associated with skeletal muscle proteins whose increased ubiquitination in response to tumor burden required MuRF1. For each time point, 3-6 tibialis anterior muscle were pooled for analyses.

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