Fig. 5: Identification of the skeletal muscle proteomic signature in response to tumor burden in the presence and absence of MURF1. | Communications Biology

Fig. 5: Identification of the skeletal muscle proteomic signature in response to tumor burden in the presence and absence of MURF1.

From: Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth

Fig. 5

a Principal component analyses of the skeletal muscle proteome during the progression of KPC tumor burden in wild-type (WT) and MuRF1-/- mice. b Number of proteins showing altered abundance in response to KPC-tumor burden. c Comparison analysis of canonical pathways enriched in WT mice highlighting similarities and differences in enriched canonical pathways across the progression of cancer cachexia in WT and MuRF1-/- mice. d Abundance of proteins annotating to canonical pathways shown in c. For each time point, 3-6 tibialis anterior muscle were pooled for analyses.

Back to article page