Fig. 5: Human milk contains a diverse array of maternal cell types.
From: The cellular and immunological dynamics of early and transitional human milk
a UMAP of single-cell transcriptomes derived from HM (n = 128,016 cells). Clusters are labeled numerically (0–23) and by the dominant cell types. b Bar graph of the frequency of total cells within each cluster. Dominant cell types are listed below. c UMAP of all single-cell transcriptomes, highlighting (blue) milk synthesis gene LALBA. d UMAPs of all single-cell transcriptomes, highlighting (blue) lactocyte cells (LC) with LC1 markers (XLF6 and CLDN4) and LC2 markers (XDH and CSN1S1). e UMAPs of all single-cell transcriptomes, highlighting (blue) macrophage marker CD68, monocyte marker FCGR3A, T cell marker CD3D, NK cell marker NKG7, B cell marker CD79A (circled), and neutrophil marker CXCL8. f Heatmap of the z-scores based on gene expression of the top variable genes within each cluster and their main functionality (right).
