Fig. 7: Subsets of microglial miRNAs are differentially expressed over developmental time. | Communications Biology

Fig. 7: Subsets of microglial miRNAs are differentially expressed over developmental time.

From: Mouse microglia express unique miRNA-mRNA networks to facilitate age-specific functions in the developing central nervous system

Fig. 7: Subsets of microglial miRNAs are differentially expressed over developmental time.The alternative text for this image may have been generated using AI.

a Volcano plots of differentially expressed miRNAs of three pairwise comparisons for P6, P15 and 8-week (adult) microglia populations. Top ten miRNAs (by P value) are labelled in each plot. b Venn diagrams comparing differentially expressed (absolute logFC >1, FDR < 0.05) miRNAs from pairwise comparisons of age groups. One hundred and eighty-five miRNAs were differentially expressed in at least one comparison. c miRNA expression (n = 1073) was plotted as LogFC relative to expression at P6 to observe changes over developmental time. miRNAs with at least one significant fold change between age group transitions (P6-P15 and/or P15-W8) were categorised and coloured by their pattern of expression (i.e. up–up, up–down, down–up or down–down. Unchanging genes are coloured light grey). Presence of a point at a specific age group indicates that the specific transition as statistically significant (FDR < 0.05). d Lists of miRNAs corresponding to each category as described in (c). The largest subsets were the up–up and down–down categories, with 14 and 37 miRNAs respectively. e Gene Ontology (GO) analysis of predicted target genes (refer to methods) of consistently upregulated (up–up) and downregulated (down–down) miRNAs (related to (d)). Top 20 pathways/terms (by P value) are represented in each plot and ordered by Gene enrichment score (number of genes in the dataset represented in the specific gene set divided by the total number of genes in the specific gene set).

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