Fig. 4: Holding time representation of ramping activities. | Communications Biology

Fig. 4: Holding time representation of ramping activities.

From: Rat hippocampal CA1 region represents learning-related action and reward events with shorter latency than the lateral entorhinal cortex

Fig. 4

a Averaged PETHs of all Hold- and Hold&Reward-type activities in CA1 (left), LECs (middle), and LECd (right). PETHs were aligned with pedal-release onset (left columns) and reward onset at 0 s (right columns). Shaded regions represent 95% CIs. b Schematic of a generalized linear regression model used to determine if each Hold-type cell represents the pedal trajectories, trial time, or both. Coefficients for relevant predictors were determined with a stepwise selection process to estimate smoothed spiking activities with a summation of weighted temporal traces of the left and right pedal trajectories and elapsed time in a trial (between two sequential pedal-holding onsets) (left). P-values with Bonferroni correction of each coefficient were used to classify cells as Time-, Time&Pedal-, or Pedal-correlated cells. Proportion of Time-, Time&Pedal-, and Pedal-correlated cells for CA1, LECs, LECd, and M1 (right).

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