Fig. 3: Dysregulation of KLF11 expression causes abnormal mitochondrial morphology in RSL3 or IKE-treated LUAD cells and affects the proliferation ability and sensitivity to chemotherapeutic agents.
From: KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4
a Characteristic alterations of mitochondria in A549 cells treated with RSL3 or IKE analyzed by TEM, Scale bars: 50 nm. b, c Dysregulation of KLF11 expression affects the proliferation ability of A549 and PC9 cells. d–g Dose-toxicity curves showing the viability of A549 and PC9 cells transfected with KLF11-NC, KLF11-OE, and KLF11-KO upon CDDP or Pem treatment at the indicated concentrations for 48 h. h–k The viability of A549 and PC9 cells transfected with KLF11-NC, KLF11-OE, and KLF11-KO were measured after 24 h treatment with RSL3/IKE, RSL3/IKE+Ferr1, or RSL3/IKE+Z-VAD.
