Fig. 5: KLF11 binds to the GPX4 promoter region and represses its transcription.
From: KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4
a, b Genome-wide data from the ENCODE project and our ChIP-seq results show the solid KLF11-binding peak in the promoter region close to the TSS of GPX4. c Characteristic sequences predicted by JASPAR for transcriptional binding of KLF11. d, e ChIP-qPCR assay depicting the enrichments of KLF11 binding in A549 and PC9. f Schematic diagram showing the possible binding sites of KLF11 to the critical region of the GPX4 promoter are mutated. g Dual luciferase activity assays to analyze the fluorescence intensity of KLF11-NC and KLF11-OE with or without mutations in the GPX4 promoter region.
