Fig. 3: Metabolomic analysis of liver response to burn stimuli in aged and young mice. | Communications Biology

Fig. 3: Metabolomic analysis of liver response to burn stimuli in aged and young mice.

From: Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims

Fig. 3

a A heatmap of differentially expressed metabolites in both aged burn versus aged sham and young burn mice versus young sham ones (p < 0.05 for each comparison). The blue cluster shows metabolites with a lower level in aged burn mice, and the red cluster shows metabolites with a higher level in aged burn mice. b Network of differentially expressed genes and metabolites in both young and aged mice after burn injury (only nodes having any connections were shown). c Upstream regulators of metabolic and transcriptomic changes after the burn injury are common for both aged and young mice. Only experimentally proven data for hepatocytes and/or liver was used for the prediction. d A heatmap of differentially expressed metabolites between aged burn and young burn mice (p < 0.05). In network, red and green colors mark up- and down-regulated nodes found in either metabolomic or transcriptomic data. N = 5 per group.

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